Yes, St. John’s Wort, and Kava Kava root have been used in tincture and capsule form to treat depression and anxiety, respectively. Vitamin D, especially in D3 form, may be helpful in the treatment of some forms of depression as may other vitamins and minerals. L-Phenylalanine and L-Tyrosine are nutritional supplements which are precursors for both Epinephrine and Norepinephrine; and 5HTP and SAM-E are precursors for Serotonin. And there's a lot of overlap as well.